Exposure to Arsenic in the Air and 15-F2t-Isoprostane in Urine in a Sub-population of Inhabitants of a Copper Smelter Region

Abstract Most studies on arsenic toxicity have been conducted among populations exposed to contained in drinking water. Relatively little research concerns effects of airborne arsenic. The aim this study was determine whether there is an association between urinary 15-F2t-isoprostane (u15-F2t-IsoP) levels relation renal function (urinary creatinine and N-acetyl-β- d -glucosaminidase––uNAG) (uAs) inhabitants from copper smelter impact zone. secondary purpose the analysis assess utility a potential uAs u15-F2t-IsoP as biomarker systemic oxidative stress. Urinary 15-F2t-IsoP, NAG, were measured 967 urine samples collected 649 adult women (51.9 ± 13.2 years old) 318 men (53.8 14.9 old). Total concentration 918 using HPLC-ICP-MS. Arsenic species, such inorganic arsenic, methylarsonic acid, dimethylarsinic arsenobetaine, 255 participants with exceeding upper norm. Data analyzed multivariate linear regression logistic models. In studied population positively associated uAs. A positive correlation ( p < 0.0000) lg(uAs) found both for normal elevated observed also lg(ΣuAs) 0.0000). model, after adjustment confounders, only predictor increased (OR = 1.31, 95% CI 1.08–1.59, 0.01). Cigarette smoking proximal tubular dysfunction people uNAG above 75th quartile. chronically increase may be useful monitoring health status